Key result
Isoproterenol tightly couples high-affinity beta-receptors to adenylate cyclase stimulation and contractility in chick embryo cells.
Population
Monolayers of spontaneously contracting chick embryo ventricular cells
Design
Preclinical
Authors
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Supports beta-adrenergic signaling models in avian cells; hypothesis-generating with uncertain translation to mammalian hearts.
In chick embryo ventricular cells, there is relatively close coupling between high-affinity beta-adrenergic receptors, adenylate cyclase stimulation, and contractile response.
Marsh et al. (1987) studied this question. Isoproterenol was evaluated on cAMP accumulation and contractile response. Isoproterenol exposure in cultured chick embryo ventricular cells demonstrated close coupling between high-affinity beta-adrenergic receptors, adenylate cyclase stimulation, and contractile response.
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