September 1, 2001Molecular Biology of the CellOpen Access

Myosin Va Bound to Phagosomes Binds to F-Actin and Delays Microtubule-dependent Motility

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Population

Phagosomes purified from mouse macrophages and exogenous myosin Va from chicken brain

Comparison

Myosin Va and antibodies to myosin Va vs Normal macrophages vs dilute-lethal macrophages

Design

Preclinical

Authors

AAAhmed M. Al-HaddadHadhramout University MSMarion A. ShonnHarvard University BRBärbel RedlichUniversity of Rostock

Discussion

Member takes

Implication

Myosin Va slows phagosome centripetal transport in macrophages; hypothesis-generating for cytoskeletal motor coordination in phagocytosis.

Structured PICO

Population

Phagosomes purified from mouse macrophages (normal mice and mice homozygous for the dilute-lethal spontaneous mutation, myosin Va null) and exogenous myosin Va from chicken brain

Intervention

Myosin Va (endogenous or exogenous) and antibodies to myosin Va

Comparator

Normal macrophages vs dilute-lethal (myosin Va null) macrophages

Outcome

Phagosome binding to F-actin and retrograde transport/accumulation in the perinuclear regionsurrogate

Myosin Va mediates phagosome binding to F-actin, delaying microtubule-dependent retrograde phagosome movement toward the cell center.

Cite This Study

Al-Haddad et al. (2001) studied this question.

synapsesocial.com/papers/6a7cc3e580d29ce2cbfaba70 https://doi.org/10.1091/mbc.12.9.2742

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Implication

Myosin Va slows phagosome centripetal transport in macrophages; hypothesis-generating for cytoskeletal motor coordination in phagocytosis.

Myosin Va Bound to Phagosomes Binds to F-Actin and Delays Microtubule-dependent Motility

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myosin Va Bound to Phagosomes Binds to F-Actin and Delays Microtubule-dependent Motility

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider