High Residual Platelet Reactivity After Clopidogrel Loading and Long-Term Clinical Outcome After Drug-Eluting Stenting for Unprotected Left Main Coronary Disease
Why the study?
Does high residual platelet reactivity after clopidogrel loading increase the risk of cardiac mortality and stent thrombosis in patients undergoing DES implantation for unprotected left main disease?
Population
215 consecutive patients who underwent percutaneous coronary intervention with drug-eluting stent for…
Comparison
High residual platelet reactivity after a… vs Low residual platelet reactivity (LRPR)
Design
Cohort
Follow-up
median 19.3 months
Authors
Discussion
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Member takes
Implication
May identify high-risk left main DES patients; hypothesis-generating for reactivity-guided therapy and should not yet change practice.
Structured PICO
Does high residual platelet reactivity after clopidogrel loading increase the risk of cardiac mortality and stent thrombosis in patients undergoing DES implantation for unprotected left main disease?
P
Population
215 consecutive patients who underwent percutaneous coronary intervention with drug-eluting stent (DES) for unprotected left main disease (ULMD)
I
Intervention
High residual platelet reactivity (HRPR) after a loading dose of 600 mg of clopidogrel
C
Comparator
Low residual platelet reactivity (LRPR)
O
Outcome
Cardiac mortalityhard clinical
High residual platelet reactivity after a 600-mg clopidogrel loading dose strongly predicts long-term cardiac death and stent thrombosis in patients undergoing DES implantation for unprotected left main disease.
Cite This Study
Migliorini et al. (2009) studied this question.