August 22, 2018Blood AdvancesOpen Access

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

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Population

In vitro assays evaluating anticoagulant antidotes

Design

Preclinical

Authors

MKManu Thomas KalathottukarenUniversity of British Columbia ACA. Louise CreaghUniversity of British Columbia SASrinivas AbbinaUniversity of British Columbia

Discussion

Member takes

Implication

Differential binding supports targeted reversal selection; leaves open clinical translation from animal data.

Structured PICO

Population

In vitro assays (isothermal titration calorimetry, clotting and chromogenic FXa assays, electron microscopy) evaluating anticoagulant antidotes

Intervention

UHRA, andexanet alfa, and ciraparantag (PER977)

Outcome

Binding affinities for putative targets and neutralization activitysurrogate

In vitro testing demonstrates that UHRA and andexanet alfa have strong binding affinities and neutralization activities for their respective targets, whereas PER977 showed weak heparin binding and no binding to direct FXa inhibitors.

Cite This Study

Kalathottukaren et al. (2018) studied this question.

synapsesocial.com/papers/6a7cc672cc6f1443deba673f https://doi.org/10.1182/bloodadvances.2016003616

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Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider