Why the study?
Does andexanet alfa reverse unfractionated heparin-induced anticoagulation in vitro?
Population
In vitro enzymatic assays, human plasma, and whole blood
Comparison
Andexanet alfa (AnXa) vs Protamine sulfate and di-arginine piperazine
Design
Preclinical
Authors
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Andexanet alfa reverses unfractionated heparin anticoagulation in vitro; leaves open clinical role as universal antidote.
Does andexanet alfa reverse unfractionated heparin-induced anticoagulation in vitro?
In vitro data demonstrate that andexanet alfa can effectively reverse the anticoagulant effects of unfractionated heparin, suggesting its potential as a universal antidote for factor Xa inhibitors and heparin.
Lu et al. (2015) studied this question.
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