June 1, 2001Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Enhanced regional AT2-receptor and PKCε expression during cardioprotection induced by AT1-receptor blockade after reperfused myocardial infarction

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Why the study?

Does candesartan improve LV function and reduce infarct size in a dog model of reperfused myocardial infarction?

Population

30 dogs with reperfused anterior infarction (90 minutes ischaemia, 120 minutes reperfusion)

Comparison

Candesartan alone or after intracoronary… vs Controls

Design

Preclinical

Follow-up

120 minutes reperfusion

Authors

BJBodh I. JugduttUniversity of Alberta MBMohammed BalghithKing Saud bin Abdulaziz University for Health Sciences

Discussion

Member takes

Implication

AT1 blockade may confer AT2-mediated cardioprotection in canine reperfused MI; leaves open translation to human patients.

Structured PICO

Does candesartan improve LV function and reduce infarct size in a dog model of reperfused myocardial infarction?

Population

30 dogs with reperfused anterior infarction (90 minutes ischaemia, 120 minutes reperfusion)

Intervention

Candesartan (1 mg/kg i.v. over 30 minutes pre-ischaemia) alone or after intracoronary administration of AT2-receptor blocker (PD 123319), PKC inhibitor (chelerythrine), endothelial NO synthase inhibitor (L-NMMA), and bradykinin-B2 receptor inhibitor (HOE140)

Comparator

Controls

Outcome

In vivo left ventricular (LV) function and remodelling, haemodynamics, and ex vivo infarct sizesurrogate

AT1-receptor blockade with candesartan provides cardioprotection during ischaemia-reperfusion injury via AT2-receptor activation and signalling through bradykinin, PKCε, and cGMP.

Cite This Study

Jugdutt et al. (2001) studied this question.

synapsesocial.com/papers/6a7cc790178e986690cf8ab7 https://doi.org/10.3317/jraas.2001.015

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Enhanced regional AT2-receptor and PKCε expression during cardioprotection induced by AT1-receptor blockade after reperfused myocardial infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Enhanced regional AT2-receptor and PKCε expression during cardioprotection induced by AT1-receptor blockade after reperfused myocardial infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider