October 17, 2017Physiological ResearchOpen Access

Different Structural Alterations in Individual Conduit Arteries of SHRs Compared to Wistar Rats From the Prehypertensive Period to Late Adulthood

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Population

60 rats total: three groups of normotensive Wistar rats and age-matched spontaneously hypertensive rats aged…

Comparison

Spontaneously hypertensive rat (SHR) model vs Age-matched normotensive Wistar rats

Design

Preclinical

Follow-up

up to 52 weeks of age

Authors

FKF KristekSlovak Academy of Sciences MDMagdalena DrobnaSlovak Academy of Sciences SČSoňa ČačányiováSlovak Academy of Sciences

Discussion

Member takes

Implication

Early remodeling precedes hypertension in SHR models; hypothesis-generating and leaves open human translation.

Structured PICO

Population

60 rats total: three groups (n=10 per group) of normotensive Wistar rats and age-matched spontaneously hypertensive rats (SHRs) aged 3, 17, and 52 weeks.

Intervention

Spontaneously hypertensive rat (SHR) model

Comparator

Age-matched normotensive Wistar rats

Outcome

Structural changes of thoracic aorta (TA), carotid (CA) and iliac artery (IA) including wall thickness (WT), cross-sectional area (CSA), inner diameter (ID), and WT/ID ratiosurrogate

Structural alterations in conduit arteries of spontaneously hypertensive rats begin in the prehypertensive period and vary by artery, suggesting early, differential vascular remodeling that precedes blood pressure elevation.

Cite This Study

Kristek et al. (2017) studied this question.

synapsesocial.com/papers/6a7cc95a67e10d58fa77099b https://doi.org/10.33549/physiolres.933690

Topics

Hypertension management

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Different Structural Alterations in Individual Conduit Arteries of SHRs Compared to Wistar Rats From the Prehypertensive Period to Late Adulthood

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Different Structural Alterations in Individual Conduit Arteries of SHRs Compared to Wistar Rats From the Prehypertensive Period to Late Adulthood

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider