Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 27, 2014ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Exercise training reduced overall hospitalisation (RR 0.75; 95% CI 0.62 to 0.92) and HF-specific hospitalisation (RR 0.61; 95% CI 0.46 to 0.80), and improved quality of life, but did not significantly reduce short-term mortality (RR 0.93; 95% CI 0.69 to 1.27).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does exercise-based rehabilitation reduce mortality and hospital admissions, and improve quality of life in adults with heart failure?

Population

33 RCTs pooling 4740 adults over 18 years with heart failure, predominantly with HFrEF and NYHA classes II…

Comparison

Exercise-based rehabilitation interventions with… vs No exercise control.

Design

Meta-analysis

Follow-up

up to 12 months and >1 year

Discussion

Loading...

Member takes

Overview

Supports routine exercise training in HF to reduce hospitalizations and improve quality of life; reinforces consensus from accumulated RCT evidence.

Key Points

  • To determine the effectiveness of exercise-based rehabilitation on mortality, hospital admissions, morbidity, and health-related quality of life in adults with heart failure.
  • Updated Cochrane systematic review searching CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, and clinical trial registries from January 2008 to January 2013.
  • Identified 33 randomized controlled trials comprising 4,740 adults with heart failure (predominantly HFREF with NYHA classes II–III, as well as HFPEF) comparing exercise interventions of at least six months' follow-up to usual care controls.
  • Exercise training significantly reduced overall hospitalizations (15 trials, n=1,328: RR 0.75; 95% CI 0.62 to 0.92) and heart failure-specific admissions (12 trials, n=1,036: RR 0.61; 95% CI 0.46 to 0.80).
  • Pooled all-cause mortality showed no significant difference at up to one year of follow-up (25 trials, n=1,871: RR 0.93; 95% CI 0.69 to 1.27), but demonstrated a trend toward reduction in trials lasting longer than one year (6 trials, n=2,845: RR 0.88; 95% CI 0.75 to 1.02).
  • Health-related quality of life improved substantially on the Minnesota Living with Heart Failure questionnaire (13 trials, n=1,270: mean difference -5.8 points; 95% CI -9.2 to -2.4), with benefits remaining consistent across age, sex, and baseline heart failure severity.

Structured PICO

Does exercise-based rehabilitation reduce mortality and hospital admissions, and improve quality of life in adults with heart failure?

P
Population
33 RCTs pooling 4740 adults over 18 years with heart failure, predominantly with HFrEF and NYHA classes II and III, but also including HFpEF.
I
Intervention
Exercise-based rehabilitation interventions with six months' follow-up or longer.
C
Comparator
No exercise control (could include usual medical care).
O
Outcome
Mortality, hospitalisation admissions, morbidity and health-related quality of life.hard clinical

Exercise-based rehabilitation in heart failure significantly reduces hospital admissions and improves quality of life, though it does not significantly impact short-term mortality.

Limitations

  • Substantial statistical heterogeneity across studies in quality of life outcome
  • Small body of evidence for HFpEF
  • Small body of evidence for exclusively home-based settings

Cite This Study

A 2014 study studied this question.

synapsesocial.com/papers/6a7ccdef14211062706ee5e1https://doi.org/10.1002/14651858.cd003331.pub4
View Full Paper
Ask AI
Bookmark
Share