Why the study?
Does oral aspirin and/or antioxidant vitamins reduce major vascular events and critical leg ischaemia in outpatients with stage I-II peripheral arterial disease?
Population
366 outpatients with stage I-II peripheral arterial disease documented by angiography or ultrasound, with…
Comparison
Oral aspirin and/or oral antioxidant vitamins… vs Placebo (neither aspirin nor antioxidant vitamins)
Design
RCT, Randomized, 2 x 2 factorial design, Double-blind, placebo-controlled
Follow-up
2 years
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Supports aspirin in stage I-II PAD outpatients; extends RCT evidence to milder disease.
Does oral aspirin and/or antioxidant vitamins reduce major vascular events and critical leg ischaemia in outpatients with stage I-II peripheral arterial disease?
Low-dose aspirin (100 mg daily) significantly reduces the risk of major vascular events and critical leg ischaemia in patients with stage I-II peripheral arterial disease.
A 2007 study studied this question.
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