Population
Human endogenous HERV-K retrovirus elements (HML-2 subgroup) and Escherichia coli used for expression
Design
Preclinical
Authors
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No immediate clinical implications from recombinant HERV-K RT activity; leaves open potential roles in human genome dynamics.
The identification of biologically active reverse transcriptase enzymes encoded by human endogenous HERV-K retroviruses suggests these elements may still have biological functions, such as retrotransposition or shaping the human genome.
Berkhout et al. (1999) studied this question.
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