What question did this study set out to answer?

To assess the incidence, types, and relative risks of de novo malignancies following liver transplantation compared with a matched general population.

June 30, 2013Clinical TransplantationOpen Access

De novo malignancy post–liver transplantation: a single center, population controlled study

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To assess the incidence, types, and relative risks of de novo malignancies following liver transplantation compared with a matched general population.
Retrospective cohort study evaluated 534 Indiana residents who underwent liver transplantation between 1997 and 2004, with follow-up through August 2010 (mean follow-up: 5.7 ± 3.2 years).
Calculated standardized incidence ratios (SIRs) by comparing observed cancer cases with expected rates from the Indiana State Cancer Registry, matched for age, sex, and calendar period.
Overall, 73 recipients (13.7%) developed 80 de novo cancers, yielding cumulative 5-year and 10-year incidence rates of 11.7% and 24.8%, respectively, with solid tumors accounting for 50%, skin cancers 30%, and hematologic cancers 20%.
Compared with the matched state population, transplant recipients had significantly elevated risks for all cancers (SIR 3.1, 95% CI: 2.9–3.2), hematologic malignancies (SIR 7.1, 95% CI: 6.3–8.0), melanoma skin cancer (SIR 5.8, 95% CI: 4.7–7.0), and solid tumors (SIR 2.7, 95% CI: 2.5–2.8).

Authors

HCHemant ChatrathHagerstown Community College KBKenneth H. BermanIndiana University Health RVRaj VuppalanchiIndiana University School of Medicine

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Implication

Cohort study reveals a threefold increased risk of de novo malignancies in liver transplant recipients, highlighting the need for targeted post-transplant cancer surveillance.

Cite This Study

Chatrath et al. (2013) studied this question.

synapsesocial.com/papers/6a7ccfc2510816ccbf66e5b2 https://doi.org/10.1111/ctr.12171

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Implication

Cohort study reveals a threefold increased risk of de novo malignancies in liver transplant recipients, highlighting the need for targeted post-transplant cancer surveillance.

De novo malignancy post–liver transplantation: a single center, population controlled study

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Discussion

Implication

Cite This Study

De novo malignancy post–liver transplantation: a single center, population controlled study

Key Points

Discussion

Implication

Cite This Study

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