Why the study?
Essential hypertension is influenced by genetic factors and eNOS is considered a susceptibility gene, motivating an evaluation of the association between the eNOS rs1799983 polymorphism and hypertension.
Does the eNOS rs1799983 polymorphism increase the risk of essential hypertension?
Population
14,185 cases and 13,407 controls across 60 eligible articles
Comparison
eNOS rs1799983 polymorphism variants across five genetic models
Design
Meta-analysis of case-control studies
Authors
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eNOS rs1799983 was associated with hypertension risk; leaves open causal role and need for prospective validation.
Does the eNOS rs1799983 polymorphism increase the risk of essential hypertension?
The eNOS rs1799983 polymorphism is significantly associated with an increased risk of essential hypertension across multiple genetic models, particularly in Asian populations.
Shi et al. (2021) studied this question.
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