Key result
The eNOS intron 4 aa genotype was significantly associated with an increased risk of hypertension (adjusted OR 6.81) in this Indian population, with further risk amplification when combined with tobacco or alcohol use.
Why the study?
Are eNOS gene polymorphisms and their interaction with environmental factors associated with an increased risk of hypertension in an Indian population?
Case-Control (n=700)
No
Are eNOS gene polymorphisms and their interaction with environmental factors associated with an increased risk of hypertension in an Indian population?
Genetic variants of the eNOS gene, along with their interaction with tobacco and alcohol consumption, are significant risk factors for the development of hypertension in this Indian population.
Answers are grounded in this paper and cite their sources.
eNOS intron 4 aa genotype may identify higher-risk Indians; hypothesis-generating and should not yet change practice.
Genetic variants of eNOS gene play a significant role in the pathogenesis of hypertension. Many environmental factors have, also, been implicated in the aetiology of hypertension. We carried out an age-matched case-control study among adults. Hypertension was defined according to JNC-VII criteria and eNOS gene polymorphisms were determined by PCR and PCR followed by PCR-RFLP. eNOS intron 4 aa genotype (adjusted OR 6.81; 95% CI 2.29-20.25) and eNOS 894TT genotype (adjusted OR 7.84; 95% CI 2.57-23.96) were associated with the risk of hypertension. Tobacco users (either smoking/chewing or both) with eNOS intron 4 aa genotype (OR 14.00: 95% CI 1.20-163.37), eNOS 894GG genotype (OR 5.56: 95% CI 3.72-8.31), and eNOS T-786C CC genotype (OR 9.00: 95% CI 1.14-71.04) were at an increased risk of hypertension. Similarly a significant gene-environment interaction was observed between individuals consuming alcohol with eNOS intron 4 aa genotype (OR 12.00: 95% CI 1.20-143.73) and eNOS 894GG genotype (OR 1.95: 95% CI 1.35-2.81). The present study identified few susceptible genotypes of the eNOS gene with the risk of hypertension. Moreover, the interactive effects between the environmental factors and the risk of hypertension were dependent on the eNOS genotypes.
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Shankarishan et al. (2014) conducted a case-control in Hypertension (n=700). eNOS intron 4 aa genotype vs. eNOS intron 4 ab and bb genotypes was evaluated on Risk of hypertension (OR 6.81, 95% CI 2.29-20.25). The eNOS intron 4 aa genotype was significantly associated with an increased risk of hypertension (adjusted OR 6.81) in this Indian population, with further risk amplification when combined with tobacco or alcohol use.
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