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January 1, 2021Current Research in PhysiologyOpen Access

Investigating myocardial performance in normal and sick fetuses by abdominal Doppler signal derived indices

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Why the study?

The study aimed to determine normal values of Tei Index (TI) and modified TI (KI) for systolic and diastolic performance across gestational ages in normal fetuses and those with abnormalities.

Does the modified Tei Index (KI) derived from abdominal Doppler signals identify myocardial dysfunction in abnormal fetuses compared to normal fetuses?

Population

55 normal and 25 abnormal fetuses

Comparison

Normal fetuses vs abnormal fetuses across early, mid, and late gestational stages

Authors

AKAhsan H. KhandokerElectrophysiologyHAHaitham M. Al-AngariKing Abdulaziz UniversityFMFaezeh MarzbanradMonash University

Discussion

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Implication

Establishes gestational age-specific fetal Tei index ranges; leaves open validation before clinical adoption in abnormal pregnancies.

Structured PICO

Does the modified Tei Index (KI) derived from abdominal Doppler signals identify myocardial dysfunction in abnormal fetuses compared to normal fetuses?

P
Population
80 fetuses (55 normal and 25 abnormal with a variety of congenital heart diseases and non-CHDs) across early (<30 weeks), mid (30-35 weeks), and late (36-41 weeks) gestation
I
Intervention
Measurement of Tei Index (TI) and modified TI (KI) using Fetal Electrocardiogram Signals (FES) and Doppler Ultrasound Signal (DUS)
C
Comparator
Normal vs. abnormal fetuses, and comparison across gestational ages
O
Outcome
Values and changes in Tei Index (TI) and modified TI (KI) across gestational ages and between normal and abnormal fetusessurrogate

The modified Tei Index (KI) derived from abdominal Doppler signals may be a useful non-invasive marker for monitoring fetal myocardial development and identifying abnormalities.

Cite This Study

Khandoker et al. (2021) studied this question.

synapsesocial.com/papers/6a7cd1a3daebf5ddd2adc8c6https://doi.org/10.1016/j.crphys.2021.02.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of left ventricular filling in normally grown fetuses, growth‐restricted fetuses and fetuses of diabetic mothers1998 · 50 citations
  2. 2Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation.1990 · 119 citations
  3. 3Systolic time intervals1990 · 113 citations
  4. 4Automated Estimation of Fetal Cardiac Timing Events From Doppler Ultrasound Signal Using Hybrid Models2013 · 47 citations
  5. 5Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)2003 · 477 citations