December 1, 1997AJP Heart and Circulatory Physiology
Use of microdialysis for monitoring sympathetic and parasympathetic innervation of heart in conscious rats
Population
Conscious, freely moving rats
Design
Preclinical
Follow-up
72 hours
Authors
Discussion
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Implication
Microdialysis enables cardiac neurotransmitter sampling in awake rats; supports autonomic research but leaves open human translation.
Structured PICO
P
Population
Conscious, freely moving rats
I
Intervention
Implantation of a flexible dialysis fiber (length 14 mm) into the heart for microdialysis
O
Outcome
Detection and measurement of extracellular norepinephrine and acetylcholinesurrogate
Microdialysis is a reliable method for studying sympathetic and parasympathetic innervation of the heart in conscious, freely moving rats.
Cite This Study
Cremers et al. (1997) studied this question.