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March 1, 1997AJP Heart and Circulatory Physiology

A new, concise dialysis approach to assessment of cardiac sympathetic nerve terminal abnormalities

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Population

Anesthetized cats

Design

Preclinical

Authors

TYToji YamazakiShiga University of Medical ScienceTAT. AkiyamaJichi Medical UniversityHKH. KitagawaShiga University of Medical Science

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Implication

Enables mechanistic probing of cardiac sympathetic terminals in animals; leaves open translation to human disease or practice.

Structured PICO

P
Population
Anesthetized cats
I
Intervention
Cardiac dialysis with local administration of pharmacological tools (omega-conotoxin GVIA, desipramine, reserpine, tyramine)
O
Outcome
Dialysate norepinephrine (NE) concentrationssurrogate

Cardiac dialysis combined with local pharmacological agents provides a novel method to assess cardiac sympathetic nerve terminal function in vivo.

Cite This Study

Yamazaki et al. (1997) studied this question.

synapsesocial.com/papers/6a7972bd1a7b6c10bc0d9f89https://doi.org/10.1152/ajpheart.1997.272.3.h1182
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vivo monitoring of myocardial interstitial norepinephrine by dialysis technique1991 · 78 citations
  2. 2Tyramine‐induced endogenous noradrenaline efflux from in situ cardiac sympathetic nerve ending in cats2000 · 14 citations
  3. 3Use of microdialysis for monitoring sympathetic and parasympathetic innervation of heart in conscious rats1997 · 12 citations
  4. 4Adrenergic inhibition of endogenous acetylcholine release on postganglionic cardiac vagal nerve terminals2000 · 41 citations
  5. 5Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion2001 · 36 citations