Why the study?
Does short-term high-fat feeding alter myocardial glucose and fatty acid utilization mechanisms in mice?
Does short-term high-fat feeding alter myocardial glucose and fatty acid utilization mechanisms in mice?
Short-term high-fat feeding in mice increases myocardial fatty acid utilization due to early impairment in glucose transport (reduced GLUT4 content and translocation) preceding impaired insulin signaling.
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Does not support clinical dietary changes; hypothesis-generating for early HFD effects on myocardial metabolism in animal models.
Wright et al. (2009) studied this question.
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