Why the study?
Does a high-fat diet induce cardiac insulin resistance via myocardial diacylglycerol accumulation in mice?
Population
C57BL/6 mice and mice lacking malonyl CoA decarboxylase
Comparison
High-fat diet (60% kcal fat) for 3 or 10 weeks vs Low-fat diet (4% kcal fat)
Design
Preclinical
Follow-up
3 or 10 weeks
Authors
Loading...
Hypothesis-generating for DAG-mediated cardiac insulin resistance in mice; leaves open translation to human metabolic cardiomyopathy.
Does a high-fat diet induce cardiac insulin resistance via myocardial diacylglycerol accumulation in mice?
High-fat diet-induced cardiac insulin resistance in mice is associated with intra-myocardial diacylglycerol accumulation and subsequent activation of p70s6k and PKCα.
Zhang et al. (2010) studied this question.