May 12, 2016European Journal of Heart Failure
Abnormal Liver Function Tests in Acute Heart Failure: Relationship with Clinical Characteristics and Outcome in the PROTECT Study
Why the study?
Do abnormal liver function tests predict worse outcomes in patients with acute heart failure?
Population
Acute heart failure (AHF) patients enrolled in the PROTECT study
Comparison
Abnormal liver function tests at baseline and… vs Normal liver function tests
Design
Cohort
Follow-up
180 days
Authors
Discussion
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Member takes
Implication
May support LFT-based risk stratification in acute HF; hypothesis-generating and should not yet change practice.
Structured PICO
Do abnormal liver function tests predict worse outcomes in patients with acute heart failure?
P
Population
Acute heart failure (AHF) patients enrolled in the PROTECT study
I
Intervention
Abnormal liver function tests (AST, ALT, albumin) at baseline and during follow-up
C
Comparator
Normal liver function tests
O
Outcome
In-hospital death and 180-day mortalityhard clinical
Abnormal liver function tests are frequent in acute heart failure and serve as independent predictors of in-hospital and 180-day mortality.
Cite This Study
Biegus et al. (2016) studied this question.