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June 1, 1999British Journal of Haematology

Diagnostic importance of the two‐stage factor VIII:C assay demonstrated by a case of mild haemophilia associated with His1954 → Leu substitution in the factor VIII A3 domain

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Authors

DKDavid KeelingCross-Cutting CardiologyKSK. SukhuNHS Blood and TransplantGKGeoffrey Kemball‐CookRoyal Free London NHS Foundation Trust

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Keeling et al. (1999) studied this question.

synapsesocial.com/papers/6a7cd85c9e20a1edef3aa6c5https://doi.org/10.1046/j.1365-2141.1999.01460.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MUTATIONS IN A SUBGROUP OF PATIENTS WITH MILD HAEMOPHILIA A AND A FAMILIAL DISCREPANCY BETWEEN THE ONE‐STAGE AND TWO‐STAGE FACTOR VIII:C METHODS1996 · 88 citations
  2. 2A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin1997 · 198 citations
  3. 3Start of UK Confidential Haemophilia A Database: Analysis of 142 Patients by Solid Phase Fluorescent Chemical Cleavage of Mismatch1999 · 49 citations
  4. 4Functional and Immunological Assays of F VIII in 133 Haemophiliacs - Characterization of a Subgroup of Patients with Mild Haemophilia A and Discrepancy in 1- and 2-Stage Assays1988 · 55 citations
  5. 5Familial discrepancy between the one‐stage and two‐stage factor VIII methods in a subgroup of patients with haemophilia A1994 · 89 citations