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December 8, 2025BloodOpen Access

Default one-stage assay for hospitalized hemophilia A patients: A cautionary tale

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Authors

TGTheodore G. Gabig

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Overview

Case presentation reveals importance of laboratory testing in hemophilia A, suggesting reassessment of coagulation assays is vital for treatment accuracy.

Key Points

  • To highlight the implications of assay discrepancies in managing hemophilia A patients transitioning from pediatric to adult care.
  • Case presentation of a 22-year-old male with mild hemophilia A and recent spontaneous hematoma.
  • Assessment of Factor VIII activity using one-stage and two-stage coagulation assays.
  • Analysis of patient history and transition from pediatric to adult hematology.
  • Patient's Factor VIII activity levels showed significant variability between one-stage and chromogenic assays.
  • Discrepancies in assay results raised concerns regarding treatment efficacy and disease severity assessment.
  • Emphasis on the need for proper laboratory testing and coordination in hemophilia care.

Cite This Study

Theodore G. Gabig (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dbbehttps://doi.org/10.1182/blood-2025-6622
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1445 Hemophilia A: when the bleeding patient looks worse than lab testing would indicate2025
  2. 2One-stage Assay Factor VIII Activity Reflects AAV-Derived Factor VIII-Enhanced Thrombin Activation and Predicts Phenotype2026
  3. 3Chromogenic Assay : A Critical Diagnostic Tool for Accurate Diagnosis of Severe Hemophilia A2024
  4. 4Combined factor v and VIII deficiency: A mucocutaneous bleeding phenotype driven predominantly by factor VIII – a retrospective study of 34 patients2025
  5. 5Follow-up study of patients with haemophilia A receiving factor VIII2024