Why the study?
Inflammation plays a key role in the pathophysiology of hypertension, but the relevance of specific inflammatory mediators such as C-reactive protein is uncertain.
Is there an association between C-reactive protein levels and 24-hour blood pressure values in adult patients?
Is there an association between C-reactive protein levels and 24-hour blood pressure values in adult patients?
CRP may be an important biomarker of the relationship between inflammation and hypertension, though the relationship may not be linear.
May support CRP as hypertension biomarker; leaves open linearity and causality of inflammation-BP link.
Background: Inflammation plays a key role in pathophysiology of hypertension; however the relevance of specific inflammatory mediators, such as C-reactive protein (CRP) is uncertain. We conducted a systematic literature review and meta-analysis to assess the associations between CRP levels and 24-hour blood pressure (BP) values in adult patients. Methods: We performed a systematic search of PubMed/MEDLINE, Embase, Web of Science, and Scopus for human studies published between January 2013 and June 2023. We included cross-sectional and cohort studies. We excluded studies reporting clinically significant inflammation. We calculated the Pearson's correlation coefficients between 24-hour BP indices and the CRP levels weighted by the inverse of their variances. Results: = 0.94). Conclusions: CRP may be an important biomarker of the relationship between inflammation and hypertension. However, the relation may not be linear throughout the entire range of CRP values. Trial Registration: International Prospective Register of Systematic Reviews (PROSPERO) Identifier: CRD42023462606.
No takes yet. Share an insight, caveat, or question.
Sulicka‐Grodzicka et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: