Why the study?
Does exenatide improve glycemic control compared to insulin glargine in patients with type 2 diabetes suboptimally controlled with metformin and a sulfonylurea?
Population
551 patients with type 2 diabetes mellitus and inadequate glycemic control despite combination metformin and…
Comparison
Exenatide 10 microg twice daily for 26 weeks. vs Insulin glargine 1 daily dose titrated to…
Design
RCT, randomized, open-label
Follow-up
26 weeks
Authors
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Exenatide is a noninferior alternative to insulin glargine for glycemic control; confirms comparable efficacy in type 2 diabetes on metformin plus sulfonylurea.
Does exenatide improve glycemic control compared to insulin glargine in patients with type 2 diabetes suboptimally controlled with metformin and a sulfonylurea?
Exenatide and insulin glargine provide similar improvements in glycemic control for patients with type 2 diabetes on oral therapy, but exenatide is associated with weight loss and higher rates of gastrointestinal side effects.
Heine et al. (2005) studied this question.
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