Risk Factors Associated with a Low Glomerular Filtration Rate in Primary Aldosteronism
Why the study?
Is primary aldosteronism associated with worse renal impairment compared to essential hypertension, and how do targeted treatments affect GFR?
Population
816 subjects, comprising 408 patients with primary aldosteronism from the German Conn's Registry and 408…
Comparison
Primary aldosteronism; subsequent targeted… vs Hypertensive control subjects matched for age…
Design
Case-control
Authors
Discussion
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Member takes
Implication
PA may mask renal impairment vs essential hypertension; leaves open whether post-adrenalectomy GFR decline signals harm or unmasking.
Structured PICO
Is primary aldosteronism associated with worse renal impairment compared to essential hypertension, and how do targeted treatments affect GFR?
P
Population
816 subjects, comprising 408 patients with primary aldosteronism (PA) from the German Conn's Registry (treated in 5 centers) and 408 hypertensive control subjects from a population-based survey, matched 1:1 for age, sex, and body mass index.
I
Intervention
Primary aldosteronism (disease exposure); subsequent targeted treatments included adrenalectomy or spironolactone.
C
Comparator
Hypertensive control subjects matched for age, sex, and body mass index.
O
Outcome
Serum creatinine and calculated glomerular filtration rate (GFR).surrogate
Primary aldosteronism is associated with a higher prevalence of renal impairment compared to essential hypertension, and targeted treatments like adrenalectomy or spironolactone unmask this by causing a further decline in GFR.
Cite This Study
Reincke et al. (2008) studied this question.