Endothelin B Receptors on Human Endothelial and Smooth-Muscle Cells Show Equivalent Binding Pharmacology

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Population

Human umbilical vein endothelial cells, human aortic smooth-muscle cells, and human bronchial smooth-muscle…

Design

Preclinical

Authors

Discussion

Equivalent ETB pharmacology across cell lines supports consistent vascular targeting; leaves open in vivo and clinical translation.

Population

Human umbilical vein endothelial cells, human aortic smooth-muscle cells, and human bronchial smooth-muscle cells

Intervention

Endothelin receptor antagonists (PD 142893, BQ-788, SB 209670, Ro 47-0203) in the presence of BQ-123

Outcome

Binding pharmacology and rank order of potency of endothelin B receptorssurrogate

Endothelin B receptors on human endothelial and smooth-muscle cells exhibit equivalent binding pharmacology across different tissue types.

Cannot discount the possibility of more than one endothelin B-receptor subtype in humans

Flynn et al. (1998) studied this question.

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