Why the study?
Does continuous subcutaneous insulin infusion improve autonomic and somatosensory nerve function in insulin-dependent diabetic subjects?
Population
24 insulin-dependent diabetic subjects, mean age 29 +/- 7 years, diabetes duration 8 +/- 4 years
Comparison
Continuous subcutaneous insulin infusion (CSII) vs Unchanged conventional insulin therapy (CIT)
Design
RCT, randomly allocated
Follow-up
2 years
Authors
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CSII better preserves nerve function than CIT in T1D; extends evidence that intensified glycemic control mitigates neuropathy.
Does continuous subcutaneous insulin infusion improve autonomic and somatosensory nerve function in insulin-dependent diabetic subjects?
Intensified glycemic control with continuous subcutaneous insulin infusion over 2 years preserves parasympathetic and somatosensory nerve function in type 1 diabetes.
Jakobsen et al. (1988) studied this question.
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