Why the study?
Does insulin versus sulfonylurea treatment improve peripheral and autonomic nerve function in newly diagnosed male diabetics?
Population
10 newly diagnosed male diabetics
Comparison
Insulin treatment (n=6) vs Sulfonylurea treatment (n=4)
Design
Cohort
Follow-up
6 months
Authors
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May support insulin preference for motor conduction in early diabetes; hypothesis-generating given observational design and persistent autonomic dysfunction.
Does insulin versus sulfonylurea treatment improve peripheral and autonomic nerve function in newly diagnosed male diabetics?
Newly diagnosed diabetic men exhibit peripheral and autonomic nerve dysfunction at diagnosis, with motor conduction improving after insulin but not sulfonylurea treatment despite better glycemic control in the latter.
Fraser et al. (1977) studied this question.
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