Key result
Sensory and autonomic dysfunction affect ~25% of children at diabetes onset and progressively deteriorate.
Why the study?
The long-term development of diabetic neuropathy in children with newly diagnosed diabetes mellitus was not well characterized.
Population
144 children with newly diagnosed diabetes mellitus
Comparison
Nerve conduction and autonomic function over time
Design
Prospective cohort study
Follow-up
10 years
Authors
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Early neuropathy monitoring may warrant consideration in pediatric diabetes; extends adult data but remains hypothesis-generating pending trials.
Cohort (n=144)
In children with newly diagnosed diabetes, early autonomic dysfunction and sensory nerve conduction abnormalities are common and deteriorate over time, correlating with glycemic control.
Solders et al. (1997) conducted a cohort in newly diagnosed diabetes mellitus (n=144). Diabetes mellitus was evaluated on Nerve conduction and autonomic nervous function. Low sensory nerve conduction and autonomic dysfunction were present in approximately 25% of children at diabetes onset, with progressive deterioration seen after 2 years of follow-up.
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