Why the study?
The effectiveness, limitations, challenges, and supplementary investigations of CAC scoring for cardiovascular risk stratification required evaluation based on the latest research.
Does a Coronary Artery Calcium (CAC) score of zero reliably predict a low risk of major adverse cardiovascular events across diverse patient populations, including symptomatic patients and different ethnicities?
Design
Narrative review
Authors
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CAC scoring refines primary prevention risk stratification; narrative synthesis of observational data leaves optimal use in comorbidities open.
Does a Coronary Artery Calcium (CAC) score of zero reliably predict a low risk of major adverse cardiovascular events across diverse patient populations, including symptomatic patients and different ethnicities?
A CAC score of zero is a valuable prognostic tool for predicting low cardiovascular risk in asymptomatic patients, but it should not be used in isolation for symptomatic patients or diverse ethnic groups due to the risk of missing non-calcified obstructive coronary artery disease.
Pereira et al. (2025) studied this question.
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