What question did this study set out to answer?

To review the underlying mechanisms, diagnostic challenges, and clinical management strategies distinguishing central and peripheral precocious puberty from benign variants in female children.

June 17, 2025EndocrinesOpen Access

Precocious Puberty and Benign Variants in Female Children: Etiology, Diagnostic Challenges, and Clinical Management

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Authors

RPRoberto Paparella VMVittorio Maglione FTFrancesca Tarani

Discussion

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Overview

Review outlines diagnostic approaches and clinical interventions for early pubertal onset in girls, indicating strategies to separate benign variants from true pathology.

Key Points

To review the underlying mechanisms, diagnostic challenges, and clinical management strategies distinguishing central and peripheral precocious puberty from benign variants in female children.
Synthesized literature on early activation of the hypothalamic–pituitary–gonadal axis and gonadotropin-independent sex steroid excess.
Evaluated diagnostic algorithms encompassing clinical exams, hormonal assessments, imaging modalities, and genetic screening.
Central precocious puberty requires intervention with gonadotropin-releasing hormone analogs to suppress hypothalamic–pituitary–gonadal axis activation, whereas peripheral cases necessitate targeted therapies.
Benign variants, including premature thelarche and premature adrenarche, are isolated events that typically require regular clinical observation rather than medical therapy.
Prompt differential diagnosis prevents unnecessary pharmacological interventions while mitigating long-term risks, such as reduced final adult height and psychosocial distress.

Cite This Study

Paparella et al. (2025) studied this question.

synapsesocial.com/papers/6a7cdf15ccf86f44befec016 https://doi.org/10.3390/endocrines6020029

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June 17, 2025EndocrinesOpen Access

Precocious Puberty and Benign Variants in Female Children: Etiology, Diagnostic Challenges, and Clinical Management

View Full Paper

Ask AI

Bookmark

Authors

RPRoberto Paparella VMVittorio Maglione FTFrancesca Tarani

Discussion

Member takes

Overview

Review outlines diagnostic approaches and clinical interventions for early pubertal onset in girls, indicating strategies to separate benign variants from true pathology.

Key Points

To review the underlying mechanisms, diagnostic challenges, and clinical management strategies distinguishing central and peripheral precocious puberty from benign variants in female children.
Synthesized literature on early activation of the hypothalamic–pituitary–gonadal axis and gonadotropin-independent sex steroid excess.
Evaluated diagnostic algorithms encompassing clinical exams, hormonal assessments, imaging modalities, and genetic screening.
Central precocious puberty requires intervention with gonadotropin-releasing hormone analogs to suppress hypothalamic–pituitary–gonadal axis activation, whereas peripheral cases necessitate targeted therapies.
Benign variants, including premature thelarche and premature adrenarche, are isolated events that typically require regular clinical observation rather than medical therapy.
Prompt differential diagnosis prevents unnecessary pharmacological interventions while mitigating long-term risks, such as reduced final adult height and psychosocial distress.

Cite This Study

Paparella et al. (2025) studied this question.

synapsesocial.com/papers/6a7cdf15ccf86f44befec016 https://doi.org/10.3390/endocrines6020029

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