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September 10, 2025Open Access

Precocious Puberty in Girls: Pathogenesis, Genetic Architecture and Emerging Molecular Therapies

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Authors

TAT. ArulmaniGSG SivakumarDSD.K. Shanmuganathan

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Overview

This review discusses the causes and therapies for precocious puberty in girls, indicating genetic and environmental impacts.

Key Points

  • Precocious puberty can lead to significant long-term health and psychosocial consequences, especially in females.
  • The onset of puberty before age 8 in girls is often driven by dysfunctional neuroendocrine signaling pathways.
  • Therapies primarily use gonadotropin-releasing hormone agonists to manage early puberty activation.
  • Future treatments may include kisspeptin antagonists and gene-based strategies targeting specific pathways.

Cite This Study

Arulmani et al. (2025) studied this question.

synapsesocial.com/papers/68c1925e9b7b07f3a0617363https://doi.org/10.38124/ijisrt/25aug1426
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic, neuropeptidergic, and cardiometabolic interplay in female central precocious puberty2025
  2. 2Precocious Puberty and Benign Variants in Female Children: Etiology, Diagnostic Challenges, and Clinical Management2025 · 4 citations
  3. 3Contemporary approach to the diagnosis and treatment of precocious puberty in children: A literature review2026
  4. 4Understanding Precocious Puberty: When Childhood Ends Too Soon2025
  5. 5Exploring the Rise in Precocious Puberty: Interplay of Genetic and Environmental Factors2024 · 2 citations