Why the study?
Does the timing of rivaroxaban administration influence ex vivo global coagulation assays in patients undergoing major orthopaedic surgery?
Population
47 patients undergoing major orthopaedic surgery receiving rivaroxaban for venous thromboembolism prophylaxis
Comparison
Rivaroxaban 10 mg daily vs Baseline and various time points after…
Design
Cohort
Follow-up
Up to day 4-5 after surgery
Authors
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Rivaroxaban significantly prolongs factor Xa-dependent routine coagulation assays 2 hours post-administration, suggesting blood samples should be drawn directly before drug administration to minimize interference.
Does the timing of rivaroxaban administration influence ex vivo global coagulation assays in patients undergoing major orthopaedic surgery?
Rivaroxaban significantly prolongs factor Xa-dependent routine coagulation assays 2 hours post-administration, suggesting blood samples should be drawn directly before drug administration to minimize interference.
Hesse et al. (2011) studied this question.
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