Why the study?
Does magnesium infusion alter vulnerability to fibrillation in anaesthetized pigs under varying conditions of heart rate and myocardial perfusion?
Population
Anaesthetized, open-chest pigs
Comparison
Magnesium i.v. infusion vs Baseline conditions without magnesium
Design
Preclinical
Authors
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Magnesium's ischemia-dependent effects on fibrillation threshold warrant clinical caution; leaves open its net role in human arrhythmia prevention.
Does magnesium infusion alter vulnerability to fibrillation in anaesthetized pigs under varying conditions of heart rate and myocardial perfusion?
Magnesium exhibits profibrillatory or antifibrillatory effects depending on plasma concentration, heart rate, and myocardial perfusion in a porcine model.
AUPET et al. (1997) studied this question.
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