Threonine 69 is a novel phosphorylation site in FXYD1 that, when phosphorylated by PKC, elicits stimulation of the cardiac sodium pump in addition to that induced by S63 and S68 phosphorylation.
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Leaves open in vivo relevance of T69 phosphorylation for cardiac sodium pump; hypothesis-generating without clinical implications.
Fuller et al. (2009) studied this question.
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