Key result
Unphosphorylated FXYD1 inhibits Na/K ATPase currents, whereas S68 phosphorylated FXYD1 stimulates Na/K ATPase to a level above that seen in the absence of FXYD1.
p-value: p=<0.05
Unphosphorylated FXYD1 inhibits Na/K ATPase, whereas S68 phosphorylated FXYD1 stimulates it above baseline levels in mouse ventricular myocytes.
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FXYD1 phosphorylation state may tune cardiac Na/K ATPase activity; hypothesis-generating and leaves open human disease relevance.
Pavlović et al. (2007) studied this question. FXYD1(54-72) peptide (unphosphorylated and S68 phosphorylated) vs. Baseline (before peptide introduction) was evaluated on K-sensitive Na/K ATPase currents (p=<0.05). Unphosphorylated FXYD1 inhibits Na/K ATPase currents, whereas S68 phosphorylated FXYD1 stimulates Na/K ATPase to a level above that seen in the absence of FXYD1.
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