Why the study?
Does radiofrequency ablation using lower osmolarity irrigants (D5W, HNS) increase lesion size compared to normal saline in preclinical models?
Population
Ex vivo viable bovine myocardium and in vivo porcine epicardium models
Comparison
Radiofrequency ablation using half normal saline… vs Radiofrequency ablation using standard normal…
Design
Preclinical
Authors
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Should not alter irrigant selection in patients; leaves open translation of larger lesions to clinical outcomes.
Does radiofrequency ablation using lower osmolarity irrigants (D5W, HNS) increase lesion size compared to normal saline in preclinical models?
Using lower osmolarity irrigants such as dextrose water or half normal saline during radiofrequency ablation increases energy delivery to tissue, resulting in larger lesions compared to standard normal saline.
Nguyen et al. (2015) studied this question.
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