October 1, 1979European Journal of Biochemistry
The Role of Calmodulin in the Structure and Regulation of Phosphorylase Kinase from Rabbit Skeletal Muscle
Population
Rabbit skeletal muscle extracts, ICR/IAn mice, and C3H/He-mg mice
Comparison
Addition of calmodulin, troponin-I, or… vs Absence of calmodulin or normal mice (C3H/He-mg)
Design
Preclinical
Authors
Discussion
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Implication
Supports dual calmodulin regulation of phosphorylase kinase; leaves open relevance to human cardiac glycogen metabolism.
Structured PICO
P
Population
Rabbit skeletal muscle extracts, ICR/IAn mice (lack muscle phosphorylase kinase activity), and C3H/He-mg mice (normal activity)
I
Intervention
Addition of calmodulin, troponin-I, or trifluoperazine
C
Comparator
Absence of calmodulin or normal mice (C3H/He-mg)
O
Outcome
Phosphorylase kinase activity and calmodulin bindingsurrogate
Calmodulin is an integral subunit of phosphorylase kinase and an additional calmodulin molecule can further stimulate its activity.
Cite This Study
Shenolikar et al. (1979) studied this question.