Population
Chinese hamster ovary (CHO)-K1 cells
Comparison
Transient transfection with rat ClC-3 vs Nontransfected CHO-K1 cells
Design
Preclinical
Authors
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Questions ClC-3 as universal swelling-activated Cl channel; leaves open its cardiac roles pending further study.
ClC-3 is an extremely outward rectifying channel that is not activated by cell swelling, suggesting it is not responsible for the swelling-activated chloride channel under all circumstances.
Li et al. (2000) studied this question.
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