March 26, 2023Amino AcidsOpen Access

Glycine protects against doxorubicin-induced heart toxicity in mice

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Why the study?

Doxorubicin is a cancer chemotherapeutic whose toxic effect on the heart limits clinical application, prompting the evaluation of glycine to counteract doxorubicin-induced cardiomyopathy.

Does glycine prevent doxorubicin-induced heart toxicity in a mouse model?

Population

Fifty male albino mice

Comparison

Glycine (100, 150, and 200 mg/kg) co-treatment vs DOXO alone vs control

Design

Five-group animal study

Authors

MSMayada I. ShoshaDamietta University FEFawzia Z. El‐AblackDamietta University ESEntsar A. SaadDamietta University

Discussion

Member takes

Implication

Glycine attenuated doxorubicin cardiomyopathy in mice; hypothesis-generating and leaves open any human translation.

Structured PICO

Does glycine prevent doxorubicin-induced heart toxicity in a mouse model?

Population

50 adult male albino mice (20-25 g)

Intervention

Glycine (100, 150, or 200 mg/kg/day i.p.) for 10 days concomitant with doxorubicin

Comparator

Doxorubicin alone (15 mg/kg total dose i.p. over 10 days) and normal saline control

Outcome

Histopathological alterations in heart tissue and biochemical markers of heart function (CPK, LDH, AST), inflammation, and oxidative stresssurrogate

Glycine co-administration dose-dependently ameliorates doxorubicin-induced cardiotoxicity in mice by reducing oxidative stress and inflammation.

Cite This Study

Shosha et al. (2023) studied this question.

synapsesocial.com/papers/6a7cec595ea1f309fbcd8d7f https://doi.org/10.1007/s00726-023-03261-w

Topics

Cardiomyopathy

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Glycine protects against doxorubicin-induced heart toxicity in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Glycine protects against doxorubicin-induced heart toxicity in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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