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October 14, 1982New England Journal of Medicine

The Effect of Treatment on Mortality in Mild Hypertension

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Why the study?

Does intensive stepped-care treatment reduce five-year mortality in patients with mild hypertension compared to usual community care?

Population

7,825 participants with mild hypertension from the Hypertension Detection and Follow-up Program

Comparison

Intensive treatment in special clinics vs Referred to usual source of care in the community

Design

RCT

Follow-up

5 years

Discussion

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Implication

Supports stepped-care intensification in mild hypertension; confirms mortality benefit versus usual care in this RCT.

Structured PICO

Does intensive stepped-care treatment reduce five-year mortality in patients with mild hypertension compared to usual community care?

P
Population
7,825 participants with mild hypertension (diastolic blood pressures averaging between 90 and 104 mm Hg on entry, designated Stratum 1) from the Hypertension Detection and Follow-up Program
I
Intervention
Intensive treatment in special clinics (stepped-care group)
C
Comparator
Referred to usual source of care in the community (referred-care group)
O
Outcome
Five-year mortalityhard clinical

Intensive stepped-care treatment significantly reduces five-year mortality in patients with mild hypertension compared to usual community care, supporting early treatment before end-organ damage occurs.

Cite This Study

A 1982 study studied this question.

synapsesocial.com/papers/6a7ceca43d640844b95e022chttps://doi.org/10.1056/nejm198210143071603

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group1979 · 503 citations
  2. 2Should Mild Hypertension Be Treated?1982 · 133 citations
  3. 3Five-year findings of the hypertension detection and follow-up program. II. Mortality by race-sex and age. Hypertension Detection and Follow-up Program Cooperative Group1979 · 89 citations
  4. 4Five-year findings of the hypertension detection and follow-up program. III. Reduction in stroke incidence among persons with high blood pressure. Hypertension Detection and Follow-up Program Cooperative Group1982 · 78 citations
  5. 5Patient Participation in a Hypertension Control Program1978 · 26 citations