Why the study?
Does olmesartan reduce sitting cuff DBP more effectively than losartan, valsartan, or irbesartan in patients with essential hypertension?
Population
588 patients with essential hypertension, predominantly white, approximately 62% male, mean age…
Comparison
Olmesartan 20 mg once daily for 8 weeks vs Losartan 50 mg, valsartan 80 mg, and irbesartan…
Design
RCT, randomized, double-blind
Follow-up
8 weeks
Authors
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May warrant preferring olmesartan over other ARBs for DBP control; extends head-to-head RCT evidence on ARB efficacy.
Does olmesartan reduce sitting cuff DBP more effectively than losartan, valsartan, or irbesartan in patients with essential hypertension?
Olmesartan 20 mg once daily is more effective than starting doses of losartan, valsartan, and irbesartan in reducing cuff DBP in patients with essential hypertension.
Oparil et al. (2001) studied this question.
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