Why the study?
Do ultrasmall NaGdF4 nanodots improve MR angiography and atherosclerotic plaque imaging in a rabbit model?
Do ultrasmall NaGdF4 nanodots improve MR angiography and atherosclerotic plaque imaging in a rabbit model?
Ultrasmall NaGdF4 nanodots demonstrate high relaxivity and enable efficient MR angiography and early detection of atherosclerotic plaques in a preclinical model.
May advance preclinical MR angiography; leaves open human translation for atherosclerotic plaque imaging.
Herein, ultrasmall NaGdF4 nanodots (~2 nm) with DTPA conjugation have been synthesized for efficient MR angiography. Impressively, the r1 value in MRI reaches up to 8.93 mM−1·s−1. The ultrasmall vessel lumen of a rabbit is lighted up remarkably. After 3 h, atherosclerotic plaques could be discriminated clearly. This is beneficial for the accurate early diagnosis of vascular pathema.
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Xing et al. (2014) studied this question.
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