Why the study?
Inflammation of epicardial adipose tissue is thought to contribute to coronary artery disease, leading to the hypothesis that epicardial fat in CAD patients has increased inflammatory gene expression.
Does the presence of coronary artery disease increase inflammatory gene expression in human epicardial adipose tissue compared to controls?
Does the presence of coronary artery disease increase inflammatory gene expression in human epicardial adipose tissue compared to controls?
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No increased inflammatory gene expression in EAT of CAD patients; challenges prior hypotheses and leaves open depot-specific mechanisms.
Fitzgibbons et al. (2019) studied this question.
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