Key result
Proteomic analysis of EAT and SAT identifies hundreds of differentially expressed proteins linked to CAD.
Why the study?
Owing to its unique anatomical structure and metabolism, epicardial adipose tissue has attracted attention in CAD research, prompting analysis of proteome differences between epicardial and subcutaneous adipose tissues in patients with or without CAD.
What are the differences in proteome composition in epicardial and subcutaneous adipose tissues between patients with and without coronary artery disease?
Population
6 CAD patients and 6 non-CAD patients
Comparison
EAT vs SAT in CAD patients compared to non-CAD patients
Design
Comparative proteomic analysis
Authors
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Hypothesis-generating for epicardial adipose proteomic signatures in CAD; requires prospective validation before clinical translation.
Observational (n=12)
What are the differences in proteome composition in epicardial and subcutaneous adipose tissues between patients with and without coronary artery disease?
Proteomic analysis reveals significant differences in epicardial adipose tissue proteins between CAD and non-CAD patients, highlighting pathways like mitochondrial dysfunction and LXR/RXR activation.
Zhao et al. (2019) conducted an observational in Coronary artery disease (n=12). Proteome analysis of epicardial and subcutaneous adipose tissues vs. Non-CAD patients was evaluated on Differentially expressed proteins in EAT and SAT. Proteomic analysis of epicardial and subcutaneous adipose tissues identified 385 and 210 differentially expressed proteins, respectively, in CAD patients compared to non-CAD patients.
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