Why the study?
Is high-grade left internal carotid artery atherosclerosis associated with an increased likelihood of dementia?
Is high-grade left internal carotid artery atherosclerosis associated with an increased likelihood of dementia?
Postmortem morphometric analysis confirms that high-grade left internal carotid stenosis is significantly associated with an increased likelihood of dementia.
Should not yet change carotid screening practices; leaves open causal contribution to dementia.
BACKGROUND AND PURPOSE: Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. METHODS: Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied. RESULTS: High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia. CONCLUSIONS: The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
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Suemoto et al. (2011) studied this question.
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