Why the study?
Do single oral doses of candesartan cilexetil (8 mg or 16 mg) improve blood pressure and renin response compared to losartan 50 mg or placebo in sodium-depleted normotensive subjects?
Population
16 sodium-depleted normotensive subjects
Comparison
Single oral doses of candesartan cilexetil at 8… vs Single oral dose of losartan 50 mg and placebo
Design
RCT, double-blind
Follow-up
24 h
Authors
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Supports 16 mg candesartan for sustained BP reduction in sodium-depleted subjects; extends ARB dose-response data versus losartan.
Do single oral doses of candesartan cilexetil (8 mg or 16 mg) improve blood pressure and renin response compared to losartan 50 mg or placebo in sodium-depleted normotensive subjects?
A single 16 mg dose of candesartan cilexetil produces greater pharmacodynamic effects on renin and blood pressure than 50 mg losartan or 8 mg candesartan in sodium-depleted normotensive subjects.
Azizi et al. (1999) studied this question.
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