Why the study?
Does candesartan cilexetil 8 mg improve blood pressure reduction compared to losartan 50 mg or placebo in patients with mild-to-moderate essential hypertension?
Population
256 patients with mild-to-moderate essential hypertension (diastolic blood pressure: 95-115 mmHg)
Comparison
Candesartan cilexetil 8 mg once daily for 6 weeks vs Losartan 50 mg once daily or placebo for 6 weeks
Design
RCT, randomised, double-blind
Follow-up
6 weeks
Authors
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Supports preferring candesartan 8 mg over losartan 50 mg for DBP reduction in mild hypertension; extends comparative ARB efficacy data from this RCT.
Does candesartan cilexetil 8 mg improve blood pressure reduction compared to losartan 50 mg or placebo in patients with mild-to-moderate essential hypertension?
Candesartan 8 mg provides greater and more consistent 24-hour blood pressure reduction than losartan 50 mg in patients with mild-to-moderate essential hypertension.
Baguet et al. (2006) studied this question.
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