Why the study?
Does dose-dependent ACE inhibition or AT1-receptor blockade improve cardiac function and normalize ANF and SR Ca(2+)-ATPase gene expression in renal hypertensive rats?
Population
Renal hypertensive rats (2K-1C model)
Comparison
ACE inhibitor benazepril or AT1-receptor… vs Placebo
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating in renal hypertensive rats; leaves open translation to human LV remodeling or dosing.
Does dose-dependent ACE inhibition or AT1-receptor blockade improve cardiac function and normalize ANF and SR Ca(2+)-ATPase gene expression in renal hypertensive rats?
High-dose ACE inhibition or AT1-receptor blockade is required to normalize systolic wall stress and restore normal SR Ca(2+)-ATPase and ANF gene expression in renal hypertensive rats.
Zierhut et al. (1996) studied this question.
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