Why the study?
Do losartan, enalapril, or amlodipine reduce cardiac hypertrophy and alter gene expression in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP) treated from 16 to 24 weeks of age
Comparison
Losartan, enalapril, or amlodipine orally for 8… vs Vehicle (control)
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
May support AT1 blockade for LV molecular reversal in hypertensive models; hypothesis-generating, requiring human trials before any clinical inference.
Do losartan, enalapril, or amlodipine reduce cardiac hypertrophy and alter gene expression in stroke-prone spontaneously hypertensive rats?
Hypertension-induced left ventricular molecular changes and hypertrophy are mediated in part by local angiotensin II via the AT1 receptor, which can be reversed by losartan.
Kim et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: