Key result
Losartan and enalapril completely inhibited the age-related increase in systolic blood pressure in SHR and reduced left ventricular ANP mRNA, but had no effect on left ventricular ADM gene expression.
Why the study?
Does losartan or enalapril affect cardiac ADM, ANP, and BNP gene expression in normotensive and hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Losartan or enalapril orally for 10 weeks vs Untreated control rats (implied)
Design
Preclinical
Follow-up
10 weeks
Authors
Loading...
ADM expression unaffected by BP control unlike ANP in SHR; leaves open its value as a cardiac load marker.
Does losartan or enalapril affect cardiac ADM, ANP, and BNP gene expression in normotensive and hypertensive rats?
Ventricular ADM synthesis is an insensitive marker of changes in hemodynamic load or cardiac hypertrophy compared to ANP and BNP.
Magga et al. (1999) studied Hypertension. Losartan or enalapril was evaluated on Effects on systolic blood pressure, cardiac hypertrophy, ANP, BNP and ADM mRNA and immunoreactive levels. Losartan and enalapril completely inhibited the age-related increase in systolic blood pressure in SHR and reduced left ventricular ANP mRNA, but had no effect on left ventricular ADM gene expression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: